Part 1: Theoretical Background

Aim: To study the efficiency of given suspending agents on the stability of a suspension.

Objectives:

• To compare different suspending agents.
• To evaluate their effect on sedimentation and suspension stability.

Requirements: Paracetamol, Ibuprofen, Azithromycin, Water, Suspending Agents (Xanthan Gum, NaCMC, Tragacanth, Bentonite, Acacia), Measuring Cylinder, Timer, Spatula, Beaker.

Principle: Suspending agents increase viscosity and reduce the rate of sedimentation. A good suspending agent minimizes the sedimentation ratio.

Equation: Sedimentation Ratio (F) = Vu / Vo

Procedure:

1. Select drug, suspending agent, and concentration.
2. Mix selected suspending agent in water vehicle.
3. Add drug and make up to volume.
4. Apply number of inversions to disperse.
5. Observe sediment volume and calculate sedimentation ratio.

Part 2: Experiment Simulation

Select Drug: Paracetamol Ibuprofen Azithromycin
Select Suspending Agent: Xanthan Gum NaCMC Tragacanth Bentonite Acacia
Concentration (%): 0.25% 0.5% 1% 1.5% 2%
Suspension Volume (mL): 50 100 150 200
No. of Inversions: 2 4 6 8 10
Simulate Reset